Relationship between soluble MICA and the MICA A5. 1 homozygous genotype in patients with oral squamous cell carcinoma
S Tamaki, M Kawakami, Y Yamanaka, H Shimomura… - Clinical …, 2009 - Elsevier
NK and cytotoxic T cells play an important role in the elimination of virus-infected and tumor
cells through NKG2D activating receptors, which can promote the lysis of target cells by
binding to the major histocompatibility complex class I-related chain A (MICA) proteins.
Polymorphisms in MICA may influence its binding to the NKG2D. The soluble form of MICA
is released from the surface of tumor cells of epithelial origin. Whereas MICA expressed on
the cell surface stimulates the immunoreceptor natural killer group 2, member D (NKG2D) …
cells through NKG2D activating receptors, which can promote the lysis of target cells by
binding to the major histocompatibility complex class I-related chain A (MICA) proteins.
Polymorphisms in MICA may influence its binding to the NKG2D. The soluble form of MICA
is released from the surface of tumor cells of epithelial origin. Whereas MICA expressed on
the cell surface stimulates the immunoreceptor natural killer group 2, member D (NKG2D) …