Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: extensive polymorphisms and evidence of diversity between …
A Antoun, S Jobson, M Cook, CA O'Callaghan… - Human immunology, 2010 - Elsevier
NKG2D is an important activating receptor on NK cells and T-cells and has a diverse panel
of ligands (NKG2DL) which include the ULBP and RAET1 proteins. Several NKG2DL exhibit
a considerable degree of genetic polymorphism, and although the functional significance of
such allelic variation remains unclear, genetic variants have been implicated in susceptibility
to infection and auto-immune disease. We used sequence-specific primer polymerase chain
reaction to determine the frequency of 25 single nucleotide polymorphisms (SNPs) in the …
of ligands (NKG2DL) which include the ULBP and RAET1 proteins. Several NKG2DL exhibit
a considerable degree of genetic polymorphism, and although the functional significance of
such allelic variation remains unclear, genetic variants have been implicated in susceptibility
to infection and auto-immune disease. We used sequence-specific primer polymerase chain
reaction to determine the frequency of 25 single nucleotide polymorphisms (SNPs) in the …
