Cardiac fatty acid uptake and transport in health and disease
GJ van der Vusse, M van Bilsen… - Cardiovascular …, 2000 - academic.oup.com
GJ van der Vusse, M van Bilsen, JFC Glatz
Cardiovascular research, 2000•academic.oup.comFatty acids are important energy donors for the healthy heart. These substrates are supplied
to the myocardium bound to albumin to overcome their low solubility in aqueous solutions
such as blood plasma. Transport from the microvasular compartment to the mitochondria
inside the cardiomyocytes is most likely a combination of passive and protein-mediated
diffusion. Alterations in tissue content of fatty acid-transport proteins may contribute to
myocardial diseases such as the diabetic heart, and cardiac hypertrophy and failure.
to the myocardium bound to albumin to overcome their low solubility in aqueous solutions
such as blood plasma. Transport from the microvasular compartment to the mitochondria
inside the cardiomyocytes is most likely a combination of passive and protein-mediated
diffusion. Alterations in tissue content of fatty acid-transport proteins may contribute to
myocardial diseases such as the diabetic heart, and cardiac hypertrophy and failure.
Abstract
Fatty acids are important energy donors for the healthy heart. These substrates are supplied to the myocardium bound to albumin to overcome their low solubility in aqueous solutions such as blood plasma. Transport from the microvasular compartment to the mitochondria inside the cardiomyocytes is most likely a combination of passive and protein-mediated diffusion. Alterations in tissue content of fatty acid-transport proteins may contribute to myocardial diseases such as the diabetic heart, and cardiac hypertrophy and failure.
Oxford University Press