Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells
JA O'Sullivan, DJ Carroll, Y Cao, AN Salicru… - Journal of Allergy and …, 2018 - Elsevier
Background Sialic acid–binding immunoglobulin-like lectin (Siglec)-8 is a cell-surface
protein expressed selectively on human eosinophils, mast cells, and basophils, making it an
ideal target for the treatment of diseases involving these cell types. However, the effective
delivery of therapeutic agents to these cells requires an understanding of the dynamics of
Siglec-8 surface expression. Objectives We sought to determine whether Siglec-8 is
endocytosed in human eosinophils and malignant mast cells, identify mechanisms …
protein expressed selectively on human eosinophils, mast cells, and basophils, making it an
ideal target for the treatment of diseases involving these cell types. However, the effective
delivery of therapeutic agents to these cells requires an understanding of the dynamics of
Siglec-8 surface expression. Objectives We sought to determine whether Siglec-8 is
endocytosed in human eosinophils and malignant mast cells, identify mechanisms …
