Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial
RF Riemersma-van Der Lek, DF Swaab, J Twisk… - Jama, 2008 - jamanetwork.com
Context Cognitive decline, mood, behavioral and sleep disturbances, and limitations of
activities of daily living commonly burden elderly patients with dementia and their
caregivers. Circadian rhythm disturbances have been associated with these symptoms.
Objective To determine whether the progression of cognitive and noncognitive symptoms
may be ameliorated by individual or combined long-term application of the 2 major
synchronizers of the circadian timing system: bright light and melatonin. Design, Setting, and …
activities of daily living commonly burden elderly patients with dementia and their
caregivers. Circadian rhythm disturbances have been associated with these symptoms.
Objective To determine whether the progression of cognitive and noncognitive symptoms
may be ameliorated by individual or combined long-term application of the 2 major
synchronizers of the circadian timing system: bright light and melatonin. Design, Setting, and …