Leukocyte-reduced red blood cell transfusions in patients with anemia and human immunodeficiency virus infection: the Viral Activation Transfusion Study: a …
AC Collier, LA Kalish, MP Busch, T Gernsheimer… - JAMA, 2001 - jamanetwork.com
ContextAllogeneic blood transfusions have immunomodulatory effects and have been
associated with activation of human immunodeficiency virus (HIV) and cytomegalovirus
(CMV) in vitro and of HIV in small pilot studies. Retrospective studies suggest that
transfusions adversely affect the clinical course of HIV. Data in selected non–HIV-infected
patients requiring blood transfusion have suggested clinical benefit with leukocyte-reduced
red blood cells (RBCs). ObjectiveTo compare the effects of leukoreduced and unmodified …
associated with activation of human immunodeficiency virus (HIV) and cytomegalovirus
(CMV) in vitro and of HIV in small pilot studies. Retrospective studies suggest that
transfusions adversely affect the clinical course of HIV. Data in selected non–HIV-infected
patients requiring blood transfusion have suggested clinical benefit with leukocyte-reduced
red blood cells (RBCs). ObjectiveTo compare the effects of leukoreduced and unmodified …
