Stimulation of HIV-specific T cell clonotypes using allogeneic HLA
CA Almeida, P van Miert, K O'Driscoll, YM Zoet… - Cellular …, 2017 - Elsevier
We hypothesized that HIV-specific CD8 T cell clonotypes can be stimulated by allogeneic
HLA molecules. Multiple HIV-specific CD8 T cell clones were derived from 12 individuals
with chronic HIV infection, specific for 13 different HIV Gag antigens and restricted to 7
different HLA molecules. The generated T cell clones were assayed for alloreactivity against
a panel of single HLA class I expressing cell lines (SALs). HIV-specific T cells recognising at
least one allogeneic HLA molecule could be identified from 7 of 12 patients tested …
HLA molecules. Multiple HIV-specific CD8 T cell clones were derived from 12 individuals
with chronic HIV infection, specific for 13 different HIV Gag antigens and restricted to 7
different HLA molecules. The generated T cell clones were assayed for alloreactivity against
a panel of single HLA class I expressing cell lines (SALs). HIV-specific T cells recognising at
least one allogeneic HLA molecule could be identified from 7 of 12 patients tested …
