Efficacy of Sulfamethoxypyridazine in a Murine Model of Pneumocystis carinii Pneumonia

MS Bartlett, MM Shaw, JW Smith… - Antimicrobial agents …, 1998 - Am Soc Microbiol
MS Bartlett, MM Shaw, JW Smith, SR Meshnick
Antimicrobial agents and chemotherapy, 1998Am Soc Microbiol
Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against
Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects.
Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a
murine model of P. carinii and might be a candidate for testing in infected patients.
Abstract
Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patients.
American Society for Microbiology