Reconstitution of the immune system after hematopoietic stem cell transplantation in humans
Seminars in immunopathology, 2008•Springer
Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a
result, the patient is at high risk of infections. Innate immunity, including epithelial barriers,
monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By
contrast, adaptive immunity recovers much slower. B-and T-cell counts normalize during the
first months after transplantation, but in particular, T-cell immunity may remain impaired for
years. During the last decade, much of the underlying mechanisms have been identified …
result, the patient is at high risk of infections. Innate immunity, including epithelial barriers,
monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By
contrast, adaptive immunity recovers much slower. B-and T-cell counts normalize during the
first months after transplantation, but in particular, T-cell immunity may remain impaired for
years. During the last decade, much of the underlying mechanisms have been identified …
Abstract
Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.
Springer