[HTML][HTML] Donor CD4 T cell diversity determines virus reactivation in patients after HLA-matched allogeneic stem cell transplantation
J Ritter, V Seitz, H Balzer, R Gary, D Lenze… - American Journal of …, 2015 - Elsevier
Delayed reconstitution of the T cell compartment in recipients of allogeneic stem cell grafts is
associated with an increase of reactivation of latent viruses. Thereby, the transplanted T cell
repertoire appears to be one of the factors that affect T cell reconstitution. Therefore, we
studied the T cell receptor beta (TCRβ) gene rearrangements of flow cytometry–sorted CD4+
and CD8+ T cells from the peripheral blood of 23 allogeneic donors before G-CSF
administration and on the day of apheresis. For this purpose, TCRβ rearrangements were …
associated with an increase of reactivation of latent viruses. Thereby, the transplanted T cell
repertoire appears to be one of the factors that affect T cell reconstitution. Therefore, we
studied the T cell receptor beta (TCRβ) gene rearrangements of flow cytometry–sorted CD4+
and CD8+ T cells from the peripheral blood of 23 allogeneic donors before G-CSF
administration and on the day of apheresis. For this purpose, TCRβ rearrangements were …