Gene expression pattern of the epidermal growth factor receptor family and LRIG1 in renal cell carcinoma
M Thomasson, H Hedman, B Ljungberg… - BMC research …, 2012 - Springer
M Thomasson, H Hedman, B Ljungberg, R Henriksson
BMC research notes, 2012•SpringerBackground Previous studies have revealed altered expression of epidermal growth factor
receptor (EGFR)-family members and their endogenous inhibitor leucine-rich and
immunoglobulin-like domains 1 (LRIG1) in renal cell carcinoma (RCC). In this study, we
analyzed the gene expression levels of EGFR-family members and LRIG1, and their
possible associations with clinical parameters in various types of RCC. Methods Gene
expression levels of EGFR–family members and LRIG1 were analyzed in 104 RCC …
receptor (EGFR)-family members and their endogenous inhibitor leucine-rich and
immunoglobulin-like domains 1 (LRIG1) in renal cell carcinoma (RCC). In this study, we
analyzed the gene expression levels of EGFR-family members and LRIG1, and their
possible associations with clinical parameters in various types of RCC. Methods Gene
expression levels of EGFR–family members and LRIG1 were analyzed in 104 RCC …
Background
Previous studies have revealed altered expression of epidermal growth factor receptor (EGFR)-family members and their endogenous inhibitor leucine-rich and immunoglobulin-like domains 1 (LRIG1) in renal cell carcinoma (RCC). In this study, we analyzed the gene expression levels of EGFR-family members and LRIG1, and their possible associations with clinical parameters in various types of RCC.
Methods
Gene expression levels of EGFR–family members and LRIG1 were analyzed in 104 RCC samples, including 81 clear cell RCC (ccRCC), 15 papillary RCC (pRCC), and 7 chromophobe RCC (chRCC) by quantitative real-time RT-PCR. Associations between gene expression levels and clinical data, including tumor grade, stage, and patient survival were statistically assessed.
Results
Compared to kidney cortex, EGFR was up-regulated in ccRCC and pRCC, LRIG1 and ERBB2 were down-regulated in ccRCC, and ERBB4 was strongly down-regulated in all RCC types. ERBB3 expression did not differ between RCC types or between RCC and the kidney cortex. The expression of the analyzed genes did not correlate with patient outcome.
Conclusions
This study revealed that the previously described up-regulation of EGFR and down-regulation of ERBB4 occurred in all analyzed RCC types, whereas down-regulation of ERBB2 and LRIG1 was only present in ccRCC. These observations illustrate the need to evaluate the different RCC types individually when analyzing molecules of interest and potential biological markers.
Springer
