The field of lipidomics, as coined in 2003, has made profound advances and been rapidly
expanded. The mass spectrometry-based strategies of this analytical methodology-oriented
research discipline for lipid analysis are largely fallen into three categories: direct infusion-
based shotgun lipidomics, liquid chromatography-mass spectrometry-based platforms, and
matrix-assisted laser desorption/ionization mass spectrometry-based approaches
(particularly in imagining lipid distribution in tissues or cells). This review focuses on shotgun …