Role of the Akt/FoxO3a pathway in TGF-β1–mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease
M Kato, H Yuan, ZG Xu, L Lanting, SL Li… - Journal of the …, 2006 - journals.lww.com
Diabetic nephropathy (DN) is characterized by mesangial cell (MC) expansion and
accumulation of extracellular matrix proteins. TGF-β is increased in MC under diabetic
conditions and in DN and activates key signaling pathways, including the phosphoinositide-
3-kinase/Akt (PI3K/Akt) pathway. FoxO transcription factors play roles in cell survival and
oxidative stress and are negatively regulated by Akt-mediated phosphorylation. We tested
whether phosphorylation-mediated inactivation of FoxO3a by TGF-β can mediate MC …
accumulation of extracellular matrix proteins. TGF-β is increased in MC under diabetic
conditions and in DN and activates key signaling pathways, including the phosphoinositide-
3-kinase/Akt (PI3K/Akt) pathway. FoxO transcription factors play roles in cell survival and
oxidative stress and are negatively regulated by Akt-mediated phosphorylation. We tested
whether phosphorylation-mediated inactivation of FoxO3a by TGF-β can mediate MC …