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by expertise, name or affiliation Antigen processing Caetano Reis e Sousa, Emil R. Unanue
Division of Immunobiology Roy and Diana Vagelos Division of Biology & Biomedical Sciences …

Ever since A. Townsend, A. McMichael, and coworkers reported 26 years ago that T
lymphocytes recognize short peptide fragments in association with major histocompatibility
complex (MHC) encoded proteins (1), immunologists have been keen to understand how
these fragments are produced, how they are transported to MHC molecules and how they
assemble with them. It was not surprising that the new fi eld of antigen processing attracted
considerable interest, given that peptide presentation by MHC molecules is the key element …