Regulation of hematopoiesis and osteogenesis by blood vessel–derived signals
SK Ramasamy, AP Kusumbe, T Itkin… - Annual review of cell …, 2016 - annualreviews.org
Annual review of cell and developmental biology, 2016•annualreviews.org
In addition to their conventional role as a versatile transport system, blood vessels provide
signals controlling organ development, regeneration, and stem cell behavior. In the skeletal
system, certain capillaries support perivascular osteoprogenitor cells and thereby control
bone formation. Blood vessels are also a critical component of niche microenvironments for
hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial
cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem …
signals controlling organ development, regeneration, and stem cell behavior. In the skeletal
system, certain capillaries support perivascular osteoprogenitor cells and thereby control
bone formation. Blood vessels are also a critical component of niche microenvironments for
hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial
cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem …
In addition to their conventional role as a versatile transport system, blood vessels provide signals controlling organ development, regeneration, and stem cell behavior. In the skeletal system, certain capillaries support perivascular osteoprogenitor cells and thereby control bone formation. Blood vessels are also a critical component of niche microenvironments for hematopoietic stem cells. Here we discuss key pathways and factors controlling endothelial cell behavior in bone, the role of vessels in osteogenesis, and the nature of vascular stem cell niches in bone marrow.
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