[HTML][HTML] Phosphorylation of α-actinin 4 upon epidermal growth factor exposure regulates its interaction with actin
H Shao, C Wu, A Wells - Journal of Biological Chemistry, 2010 - ASBMB
The ubiquitously expressed family of α-actinins bridges actin filaments to stabilize
adhesions, a process disrupted during growth factor-induced migration of cells. During the
dissolution of the actin cytoskeleton, actinins are phosphorylated on tyrosines, although the
consequences of this are unknown. We expressed the two isoforms of human α-actinin in
murine fibroblasts that express human epidermal growth factor receptor (EGFR) and found
that both α-actinin 1 (ACTN1) and α-actinin 4 (ACTN4) were phosphorylated on tyrosine …
adhesions, a process disrupted during growth factor-induced migration of cells. During the
dissolution of the actin cytoskeleton, actinins are phosphorylated on tyrosines, although the
consequences of this are unknown. We expressed the two isoforms of human α-actinin in
murine fibroblasts that express human epidermal growth factor receptor (EGFR) and found
that both α-actinin 1 (ACTN1) and α-actinin 4 (ACTN4) were phosphorylated on tyrosine …