Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue

SJ Richardson, A Willcox, DA Hilton, S Tauriainen… - Journal of clinical …, 2010 - Elsevier
BACKGROUND: The detection of viral infection in paraffin-embedded, formalin-fixed tissue
is notoriously difficult and often requires inherent knowledge about the specific virus being
sought. For this reason, there is an ongoing need for reagents and methods which can
identify a range of different virus types in paraffin embedded tissue. OBJECTIVES: The aim
of this study was to optimise and validate the use of antisera directed against dsRNA (>
50bp in length) in paraffin-embedded formalin-fixed tissue samples. STUDY DESIGN …