The cuprizone model for demyelination
Ø Torkildsen, LA Brunborg, KM Myhr… - Acta neurologica …, 2008 - Wiley Online Library
Ø Torkildsen, LA Brunborg, KM Myhr, L Bø
Acta neurologica scandinavica, 2008•Wiley Online LibraryBackground–Important advances in multiple sclerosis (MS) research have been made as a
direct or indirect result of experiments in animal models for the disease, although MS is a
disease only affecting humans. The cuprizone model is a model for toxic demyelination. In
this model, young mice are fed with the copper chelator cuprizone, leading to
oligodendrocyte death and a subsequent reversible demyelination. Spontaneous
remyelination can be seen as early as 4 days after withdrawal of cuprizone. Materials and …
direct or indirect result of experiments in animal models for the disease, although MS is a
disease only affecting humans. The cuprizone model is a model for toxic demyelination. In
this model, young mice are fed with the copper chelator cuprizone, leading to
oligodendrocyte death and a subsequent reversible demyelination. Spontaneous
remyelination can be seen as early as 4 days after withdrawal of cuprizone. Materials and …
Background – Important advances in multiple sclerosis (MS) research have been made as a direct or indirect result of experiments in animal models for the disease, although MS is a disease only affecting humans. The cuprizone model is a model for toxic demyelination. In this model, young mice are fed with the copper chelator cuprizone, leading to oligodendrocyte death and a subsequent reversible demyelination. Spontaneous remyelination can be seen as early as 4 days after withdrawal of cuprizone.
Materials and methods – This article reviews previous research on this model and discusses the potential of the model for future application in MS research.
Discussion – The cuprizone model correlates with newer histopathological data in MS and is a valuable tool for studies on de‐ and remyelination. The use of the C57BL/6 strain offers the potential for future studies on transgene and knockout mice.
Wiley Online Library