[HTML][HTML] Hypertrophic cardiomyopathy without hypertrophy: an emerging pre-clinical subgroup composed of genetically affected family members
BJ Maron, CY Ho - JACC: Cardiovascular Imaging, 2009 - jacc.org
BJ Maron, CY Ho
JACC: Cardiovascular Imaging, 2009•jacc.orgHypertrophic cardiomyopathy (HCM) is characterized by an exceedingly broad spectrum of
phenotypic expression (1–3). This disease, initially regarded as typically associated with
diffuse and particularly substantial left ventricular (LV) wall thickening and mass, has now
been shown to include morphologic forms demonstrating a wide range in the magnitude of
LV hypertrophy (3). Indeed, mild and segmental wall thickening constitutes an important
proportion of the HCM morphologic spectrum, as underscored by a recent cardiovascular …
phenotypic expression (1–3). This disease, initially regarded as typically associated with
diffuse and particularly substantial left ventricular (LV) wall thickening and mass, has now
been shown to include morphologic forms demonstrating a wide range in the magnitude of
LV hypertrophy (3). Indeed, mild and segmental wall thickening constitutes an important
proportion of the HCM morphologic spectrum, as underscored by a recent cardiovascular …
Hypertrophic cardiomyopathy (HCM) is characterized by an exceedingly broad spectrum of phenotypic expression (1–3). This disease, initially regarded as typically associated with diffuse and particularly substantial left ventricular (LV) wall thickening and mass, has now been shown to include morphologic forms demonstrating a wide range in the magnitude of LV hypertrophy (3). Indeed, mild and segmental wall thickening constitutes an important proportion of the HCM morphologic spectrum, as underscored by a recent cardiovascular magnetic resonance imaging study that showed that fully 20% of patients with a clinically expressed HCM phenotype (namely, increased LV wall thickness) paradoxically showed normal overall LV mass (4).
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