Levels of non‐transferrin‐bound iron as an index of iron overload in patients with thalassaemia intermedia
A Taher, KM Musallam, F El Rassi… - British journal of …, 2009 - Wiley Online Library
British journal of haematology, 2009•Wiley Online Library
Non‐transferrin‐bound iron (NTBI) was evaluated as an index of iron overload in a cross‐
sectional randomised study in 74 non‐transfused patients with thalassaemia intermedia (TI).
Mean NTBI (2· 92±3· 43 μmol/l), serum ferritin (1023±780 ng/ml) and liver iron concentration
(LIC; 9· 0±7· 4 mg Fe/g dry weight) were increased above reference‐range levels.
Significant positive correlations occurred between mean NTBI and LIC (Pearson correlation
0· 36; P= 0· 002) and serum ferritin (Pearson correlation 0· 421; P< 0· 0001); with higher …
sectional randomised study in 74 non‐transfused patients with thalassaemia intermedia (TI).
Mean NTBI (2· 92±3· 43 μmol/l), serum ferritin (1023±780 ng/ml) and liver iron concentration
(LIC; 9· 0±7· 4 mg Fe/g dry weight) were increased above reference‐range levels.
Significant positive correlations occurred between mean NTBI and LIC (Pearson correlation
0· 36; P= 0· 002) and serum ferritin (Pearson correlation 0· 421; P< 0· 0001); with higher …
Summary
Non‐transferrin‐bound iron (NTBI) was evaluated as an index of iron overload in a cross‐sectional randomised study in 74 non‐transfused patients with thalassaemia intermedia (TI). Mean NTBI (2·92 ± 3·43 μmol/l), serum ferritin (1023 ± 780 ng/ml) and liver iron concentration (LIC; 9·0 ± 7·4 mg Fe/g dry weight) were increased above reference‐range levels. Significant positive correlations occurred between mean NTBI and LIC (Pearson correlation 0·36; P = 0·002) and serum ferritin (Pearson correlation 0·421; P < 0·0001); with higher levels observed in splenectomised patients. NTBI assessment has potential as a simple reliable approach to determining iron status in TI.
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