Protein analysis in human cerebrospinal fluid: Physiological aspects, current progress and future challenges
AF Hühmer, RG Biringer, H Amato, AN Fonteh… - Disease …, 2006 - content.iospress.com
AF Hühmer, RG Biringer, H Amato, AN Fonteh, MG Harrington
Disease markers, 2006•content.iospress.comThe introduction of lumbar puncture into clinical medicine over 100 years ago marks the
beginning of the study of central nervous system diseases using the human cerebrospinal
fluid (CSF). Ever since, CSF has been analyzed extensively to elucidate the physiological
and biochemical bases of neurological disease. The proximity of CSF to the brain makes it a
good target for studying the pathophysiology of brain functions, but the barrier function of the
CSF also impedes its diagnostic value.
beginning of the study of central nervous system diseases using the human cerebrospinal
fluid (CSF). Ever since, CSF has been analyzed extensively to elucidate the physiological
and biochemical bases of neurological disease. The proximity of CSF to the brain makes it a
good target for studying the pathophysiology of brain functions, but the barrier function of the
CSF also impedes its diagnostic value.
Abstract
The introduction of lumbar puncture into clinical medicine over 100 years ago marks the beginning of the study of central nervous system diseases using the human cerebrospinal fluid (CSF). Ever since, CSF has been analyzed extensively to elucidate the physiological and biochemical bases of neurological disease. The proximity of CSF to the brain makes it a good target for studying the pathophysiology of brain functions, but the barrier function of the CSF also impedes its diagnostic value.
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