Background Enzalutamide, an oral androgen receptor inhibitor, significantly improved
overall survival (OS) and radiographic progression-free survival (rPFS) versus placebo in
the PREVAIL trial of men with chemotherapy-naïve metastatic castration-resistant prostate
cancer. Objective To assess the effects of enzalutamide versus placebo in patients from
PREVAIL based on site and extent of baseline disease. Design, setting, and participants
One thousand seven hundred and seventeen asymptomatic or minimally symptomatic …

Effects of sodium nitrate were compared with sodium chloride loading on transport of
electrolytes by the nephron. Maximal levels of free water clearance/clomerular filtration rate
(CH2O/GFR) averaged 8.4% with nitrate loading and 14.4% with saline loading. Since
ethacrynic acid and chlorothiazide exert their major natriuretic effect in the distal nephron,
the increment in Na ad Cl reabsorbed beyond the proximal tubule. The administration of
these agents resulted in an increase in fractional sodium excretion (CNa/GFR) of 21.1 …