[HTML][HTML] Impaired T-cell survival promotes mucosal inflammatory disease in SHIP1-deficient mice
MY Park, N Srivastava, R Sudan, DR Viernes… - Mucosal …, 2014 - Elsevier
T cells have a critical role in immune surveillance at mucosal surfaces. SHIP1−/− mice
succumb to mucosal inflammatory disease that afflicts the lung and small intestine (SI). The
basis of this condition has not been defined. Here we show that SHIP1 is required for the
normal persistence and survival of T cells in mucosal tissues. We find that CD4 and CD8
effector T cells are reduced; however, Treg cells are increased in the SI and lungs of
SHIP1−/− and CD4CreSHIP flox/flox mice. Furthermore, a subset of T cells in the SI of …
succumb to mucosal inflammatory disease that afflicts the lung and small intestine (SI). The
basis of this condition has not been defined. Here we show that SHIP1 is required for the
normal persistence and survival of T cells in mucosal tissues. We find that CD4 and CD8
effector T cells are reduced; however, Treg cells are increased in the SI and lungs of
SHIP1−/− and CD4CreSHIP flox/flox mice. Furthermore, a subset of T cells in the SI of …