Bronchiolitis obliterans syndrome is associated with increased peripheral blood natural killer and natural killer T-like granzymes, perforin, and T-helper-type 1 pro …
G Hodge, S Hodge, CL Holmes-Liew… - The Journal of heart and …, 2012 - Elsevier
BACKGROUND: We previously showed that bronchiolitis obliterans syndrome (BOS) is
associated with lack of immunosuppression of T-cell pro-inflammatory cytokines and
granzyme B. We recently showed that natural killer (NK) T (NKT)-like cells are a major
source of pro-inflammatory cytokines and granzymes in the blood of stable lung transplant
patients. NK cells also produce these pro-inflammatory mediators, and we hypothesized that
BOS may be associated with lack of immunosuppression of these pro-inflammatory …
associated with lack of immunosuppression of T-cell pro-inflammatory cytokines and
granzyme B. We recently showed that natural killer (NK) T (NKT)-like cells are a major
source of pro-inflammatory cytokines and granzymes in the blood of stable lung transplant
patients. NK cells also produce these pro-inflammatory mediators, and we hypothesized that
BOS may be associated with lack of immunosuppression of these pro-inflammatory …
