Heart failure, a complex disorder with heterogeneous aetiologies remains one of the most
threatening diseases known. It is a clinical syndrome attributable to a multitude of factors that
begins with the compensatory response known as hypertrophy, followed by a
decompensated state that finally results in heart failure. Given the lack of a unified theory of
heart failure, future research efforts are required to unify and synthesize our current
understanding of the multiple mechanisms that control remodelling in heart under various …