Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque
AP Owens III, N Mackman - Thrombosis research, 2012 - Elsevier
Hyperlipidemia leads to the formation of oxidized LDL (oxLDL), vessel dysfunction,
atherosclerotic disease, and ultimately to plaque rupture and thrombosis. OxLDL induces
tissue factor (TF) expression in various cell types, including monocytes and macrophages.
High levels of TF are present in atherosclerotic plaques and this represents that major
source of TF that triggers thrombosis after plaque rupture. In addition, increased levels of
“circulating TF” are observed in hyperlipidemic animals and patients. This is due to induced …
atherosclerotic disease, and ultimately to plaque rupture and thrombosis. OxLDL induces
tissue factor (TF) expression in various cell types, including monocytes and macrophages.
High levels of TF are present in atherosclerotic plaques and this represents that major
source of TF that triggers thrombosis after plaque rupture. In addition, increased levels of
“circulating TF” are observed in hyperlipidemic animals and patients. This is due to induced …