Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy
HM Haitchi, DJP Bassett, F Bucchieri, X Gao… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Asthma pathogenesis involves gene and environmental interactions. A
disintegrin and metalloprotease 33 (ADAM33)/Adam33 is a susceptibility gene for asthma
and bronchial hyperresponsiveness in human beings and mice. ADAM33 is almost
exclusively expressed in mesenchymal cells, including mesenchymal progenitors in
developing lungs. OBJECTIVE: Because maternal allergy is a risk factor for asthma, we
hypothesized that an allergic environment affects ADAM33/Adam33 expression during …
disintegrin and metalloprotease 33 (ADAM33)/Adam33 is a susceptibility gene for asthma
and bronchial hyperresponsiveness in human beings and mice. ADAM33 is almost
exclusively expressed in mesenchymal cells, including mesenchymal progenitors in
developing lungs. OBJECTIVE: Because maternal allergy is a risk factor for asthma, we
hypothesized that an allergic environment affects ADAM33/Adam33 expression during …