Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population
K Estrada, I Aukrust, L Bjørkhaug, NP Burtt… - Jama, 2014 - jamanetwork.com
Importance Latino populations have one of the highest prevalences of type 2 diabetes
worldwide. Objectives To investigate the association between rare protein-coding genetic
variants and prevalence of type 2 diabetes in a large Latino population and to explore
potential molecular and physiological mechanisms for the observed relationships. Design,
Setting, and Participants Whole-exome sequencing was performed on DNA samples from
3756 Mexican and US Latino individuals (1794 with type 2 diabetes and 1962 without …
worldwide. Objectives To investigate the association between rare protein-coding genetic
variants and prevalence of type 2 diabetes in a large Latino population and to explore
potential molecular and physiological mechanisms for the observed relationships. Design,
Setting, and Participants Whole-exome sequencing was performed on DNA samples from
3756 Mexican and US Latino individuals (1794 with type 2 diabetes and 1962 without …