[HTML][HTML] De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years

SM Flechner, SM Kurian, K Solez, DJ Cook… - American Journal of …, 2004 - Elsevier
We performed a randomized prospective trial comparing calcineurin inhibitor (CNI)-free to
CNI-based immunosuppression to determine the impact on renal function, structure and
gene expression. Sixty-one kidney recipients treated with basiliximab mycophenolate mofetil
(MMF) and prednisone (P) were randomly assigned to concentration-controlled sirolimus or
cyclosporine. Two years post-transplant 55 patients underwent renal function studies, 48
(87%) underwent transplant biopsies; all classified by Banff scoring and 41 by DNA …