Molecular microscope strategy to improve risk stratification in early antibody-mediated kidney allograft rejection
A Loupy, C Lefaucheur, D Vernerey… - Journal of the …, 2014 - journals.lww.com
Antibody-mediated rejection (ABMR) is the leading cause of kidney allograft loss. We
investigated whether the addition of gene expression measurements to conventional
methods could serve as a molecular microscope to identify kidneys with ABMR that are at
high risk for failure. We studied 939 consecutive kidney recipients at Necker Hospital (2004–
2010; principal cohort) and 321 kidney recipients at Saint Louis Hospital (2006–2010;
validation cohort) and assessed patients with ABMR in the first 1 year post-transplant. In …
investigated whether the addition of gene expression measurements to conventional
methods could serve as a molecular microscope to identify kidneys with ABMR that are at
high risk for failure. We studied 939 consecutive kidney recipients at Necker Hospital (2004–
2010; principal cohort) and 321 kidney recipients at Saint Louis Hospital (2006–2010;
validation cohort) and assessed patients with ABMR in the first 1 year post-transplant. In …