Negative T-cell costimulatory pathways: their role in regulating alloimmune responses
O Boenisch, MH Sayegh, N Najafian - Current opinion in organ …, 2008 - journals.lww.com
O Boenisch, MH Sayegh, N Najafian
Current opinion in organ transplantation, 2008•journals.lww.comThe understanding of negative costimulatory pathways is embarrassed by complex
interactions between simultaneously activated positive and negative costimulatory pathways
among themselves and with immunosuppressive agents, differential expression of these
molecules on different immune cell subsets as well as their expression in parenchymal cells
of transplanted tissues, all of them clearly affecting their functions. Further elucidation of
these novel concepts is pertinent for targeting these pathways in translational studies in near …
interactions between simultaneously activated positive and negative costimulatory pathways
among themselves and with immunosuppressive agents, differential expression of these
molecules on different immune cell subsets as well as their expression in parenchymal cells
of transplanted tissues, all of them clearly affecting their functions. Further elucidation of
these novel concepts is pertinent for targeting these pathways in translational studies in near …
Summary
The understanding of negative costimulatory pathways is embarrassed by complex interactions between simultaneously activated positive and negative costimulatory pathways among themselves and with immunosuppressive agents, differential expression of these molecules on different immune cell subsets as well as their expression in parenchymal cells of transplanted tissues, all of them clearly affecting their functions. Further elucidation of these novel concepts is pertinent for targeting these pathways in translational studies in near future.
Lippincott Williams & Wilkins