Blockade of PD-1/PD-L1 immune checkpoint during DC vaccination induces potent protective immunity against breast cancer in hu-SCID mice
Y Ge, H Xi, S Ju, X Zhang - Cancer letters, 2013 - Elsevier
Y Ge, H Xi, S Ju, X Zhang
Cancer letters, 2013•ElsevierImmune checkpoints, such as the PD-1/PD-L1 pathway, negatively interfere in the efficiency
of dendritic cell (DC) vaccination in cancer immunotherapy. In this study, we demonstrated
that the blockade of PD-L1 signaling could promote DC maturation, proliferation, and IL-12
secretion, augment DC primed T cell response and reverse tumor cell dampened T cell
impairment. Blockade of PD-L1 signaling during DC vaccination showed better therapeutic
effects than classic DC vaccination by preventing tumor growth and prolonging survival …
of dendritic cell (DC) vaccination in cancer immunotherapy. In this study, we demonstrated
that the blockade of PD-L1 signaling could promote DC maturation, proliferation, and IL-12
secretion, augment DC primed T cell response and reverse tumor cell dampened T cell
impairment. Blockade of PD-L1 signaling during DC vaccination showed better therapeutic
effects than classic DC vaccination by preventing tumor growth and prolonging survival …
Immune checkpoints, such as the PD-1/PD-L1 pathway, negatively interfere in the efficiency of dendritic cell (DC) vaccination in cancer immunotherapy. In this study, we demonstrated that the blockade of PD-L1 signaling could promote DC maturation, proliferation, and IL-12 secretion, augment DC primed T cell response and reverse tumor cell dampened T cell impairment. Blockade of PD-L1 signaling during DC vaccination showed better therapeutic effects than classic DC vaccination by preventing tumor growth and prolonging survival times in a breast tumor-bearing hu-SCID model. Taken together, suppressing immune checkpoints during DC vaccination might be a more efficient strategy for cancer therapy.
Elsevier
