Enhancement of vaccine-induced primary and memory CD8+ t-cell responses by soluble PD-1
MY Song, SH Park, HJ Nam, DH Choi… - Journal of …, 2011 - journals.lww.com
Abstract Programmed death 1 (PD-1) signaling through its ligands, PD-L1 and PD-L2, has
been known to negatively regulate T-cell responses. In addition, PD-L1 has been shown to
interact with B7-1 costimulatory molecule to inhibit T-cell responses. Extensive studies have
shown that PD-1/PD-L blockade restores exhausted T cells during chronic viral infections
and tumors. In this study, we evaluated the effects of soluble PD-1 (sPD-1) as a blockade of
PD-1 and PD-L1 on vaccine-elicited antigen-specific T-cell responses in mice …
been known to negatively regulate T-cell responses. In addition, PD-L1 has been shown to
interact with B7-1 costimulatory molecule to inhibit T-cell responses. Extensive studies have
shown that PD-1/PD-L blockade restores exhausted T cells during chronic viral infections
and tumors. In this study, we evaluated the effects of soluble PD-1 (sPD-1) as a blockade of
PD-1 and PD-L1 on vaccine-elicited antigen-specific T-cell responses in mice …