II. The influence of injury upon the development of sarcoma

WB Coley - Annals of surgery, 1898 - ncbi.nlm.nih.gov
WB Coley
Annals of surgery, 1898ncbi.nlm.nih.gov
DURING the past eight yearsI have had under my care, including both hospital and private
patients, I70 cases of sarcoma. This large. number of cases, of which I have careful histories,
has given me an exceptional opportunity for studying the clinical features of this disease,
and no feature, I may say, has impressed me more strongly than the frequent association of
trauma with its early manifestations. In consult-ing the literature of the subject I find that there
is a wide divergence of opinion, both as to the real facts and still more as to the probable …
DURING the past eight yearsI have had under my care, including both hospital and private patients, I70 cases of sarcoma. This large. number of cases, of which I have careful histories, has given me an exceptional opportunity for studying the clinical features of this disease, and no feature, I may say, has impressed me more strongly than the frequent association of trauma with its early manifestations. In consult-ing the literature of the subject I find that there is a wide divergence of opinion, both as to the real facts and still more as to the probable explanation of these facts. It is only by collecting and analyzing a large number of more or less closely related facts that we are able to reach important generalizations.
I believe that the subject under discussion has a most important bearing upon the etiology of sarcoma, and any-thing that can throw light upon this ought to be welcomed. Another aspect, which has of late aroused considerable interest among the German surgeons, needs but to be men-tioned to show its practical importance. This is the matter of accident insurance. If sarcoma in a large proportion of cases is really the result of an injury or an accident, the com-panies are liable; if not the result of an injury, they are not. Much is involved in settling this point. The present
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