Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients
Y Tsunemi, H Saeki, K Nakamura, T Sekiya… - Journal of …, 2002 - Elsevier
Interleukin (IL)-13 plays an important role in the induction of immunoglobulin E (IgE) and in
the pathogenesis of atopic dermatitis (AD). We investigated the allele and genotype
frequencies of three IL-13 single nucleotide polymorphisms (SNPs)(A704C and C1103T in
the promoter region and G4257A in exon 4) in Japanese patients with AD. For A704C and
C1103T SNPs, there were no significant differences in allele or genotype frequencies
between AD patients and controls. For G4257A SNP, A allele was significantly increased in …
the pathogenesis of atopic dermatitis (AD). We investigated the allele and genotype
frequencies of three IL-13 single nucleotide polymorphisms (SNPs)(A704C and C1103T in
the promoter region and G4257A in exon 4) in Japanese patients with AD. For A704C and
C1103T SNPs, there were no significant differences in allele or genotype frequencies
between AD patients and controls. For G4257A SNP, A allele was significantly increased in …