Mucosal-associated invariant T cells from patients with tuberculosis exhibit impaired immune response
J Jiang, B Yang, H An, X Wang, Y Liu, Z Cao, F Zhai… - Journal of Infection, 2016 - Elsevier
Objectives To identify factors which regulate MAIT cell response to Mycobacterium
tuberculosis antigens, and to investigate the role of MAIT cells in patients with active
tuberculosis. Methods Immune response of MAIT cells to M. tuberculosis antigens were
compared between patients with active TB and healthy controls by flow cytometry and RNA
sequencing. Results IFN-γ response of MAIT cells to M. tuberculosis lysates was
dramatically improved by signal 3 cytokine IL-15 (p= 0.0002). Patients with active TB …
tuberculosis antigens, and to investigate the role of MAIT cells in patients with active
tuberculosis. Methods Immune response of MAIT cells to M. tuberculosis antigens were
compared between patients with active TB and healthy controls by flow cytometry and RNA
sequencing. Results IFN-γ response of MAIT cells to M. tuberculosis lysates was
dramatically improved by signal 3 cytokine IL-15 (p= 0.0002). Patients with active TB …
