Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all …
Retinol dehydrogenase (RDH), the enzyme that catalyzes the reduction of all-trans-retinal to
all-trans-retinol within the photoreceptor outer segment, was the first visual cycle enzymatic
activity to be identified. Previous work has shown that this enzyme utilizes NADPH, shows a
marked preference for all-trans-retinal over 11-cis-retinal, and is tightly associated with the
outer segment membrane. This paper reports the identification of a novel member of the
short chain dehydrogenase/reductase family, photoreceptor RDH (prRDH), using …
all-trans-retinol within the photoreceptor outer segment, was the first visual cycle enzymatic
activity to be identified. Previous work has shown that this enzyme utilizes NADPH, shows a
marked preference for all-trans-retinal over 11-cis-retinal, and is tightly associated with the
outer segment membrane. This paper reports the identification of a novel member of the
short chain dehydrogenase/reductase family, photoreceptor RDH (prRDH), using …
