[HTML][HTML] A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus
MB Srichai, M Konieczkowski, A Padiyar… - Journal of Biological …, 2004 - ASBMB
Glomerular podocyte differentiation state is critical for filtration barrier function and is
regulated by WT1, a zinc finger transcription factor. A yeast two-hybrid assay identified a
novel, WT1-interacting protein (WTIP) that maps to human chromosome 19q13. 1, a region
with genes linked to familial focal segmental glomerulosclerosis. The domain structure of
WTIP is similar to the zyxin subfamily of cytosolic LIM domain-containing proteins, which
contain three carboxyl-terminal LIM protein-protein interaction domains and a proline-rich …
regulated by WT1, a zinc finger transcription factor. A yeast two-hybrid assay identified a
novel, WT1-interacting protein (WTIP) that maps to human chromosome 19q13. 1, a region
with genes linked to familial focal segmental glomerulosclerosis. The domain structure of
WTIP is similar to the zyxin subfamily of cytosolic LIM domain-containing proteins, which
contain three carboxyl-terminal LIM protein-protein interaction domains and a proline-rich …
