Phosphatase of regenerating liver 3 (PRL3) is suspected to be a causative factor toward
cellular metastasis when in excess. To date, the molecular basis for PRL3 function remains
an enigma, making efforts at distilling a concerted mechanism for PRL3-mediated metastatic
dissemination very difficult. We previously discovered that PRL3 expressing cells exhibit a
pronounced increase in protein tyrosine phosphorylation. Here we take an unbiased mass
spectrometry-based approach toward identifying the phosphoproteins exhibiting enhanced …