Oxalic acid stabilizes dopamine, serotonin, and their metabolites in automated liquid chromatography with electrochemical detection
A Kankaanpää, E Meririnne, K Ariniemi… - … of Chromatography B …, 2001 - Elsevier
Use of antioxidative agents is required in automated LC assay of microdialysis samples, due
to rapid degradation of the monoamine neurotransmitters and their metabolites. Addition of
oxalic acid prevented degradation of dopamine, serotonin, 3, 4-dihydroxyphenylacetic acid,
homovanillic acid and 5-hydroxyindoleacetic acid efficiently: after a 24-h incubation at room
temperature the decreases in peak heights were less than 10%. The long-term stability of
the analytes, however, was still enhanced when acetic acid and l-cysteine were included in …
to rapid degradation of the monoamine neurotransmitters and their metabolites. Addition of
oxalic acid prevented degradation of dopamine, serotonin, 3, 4-dihydroxyphenylacetic acid,
homovanillic acid and 5-hydroxyindoleacetic acid efficiently: after a 24-h incubation at room
temperature the decreases in peak heights were less than 10%. The long-term stability of
the analytes, however, was still enhanced when acetic acid and l-cysteine were included in …
