Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin
SJ Fairweather, A Bröer, N Subramanian… - Journal of Biological …, 2015 - ASBMB
Many solute carrier 6 (SLC6) family transporters require ancillary subunits to modify their
expression and activity. The main apical membrane neutral amino acid transporters in
mouse intestine and kidney, B 0 AT1 and B 0 AT3, require the ancillary protein collectrin or
ACE2 for plasma membrane expression. Expression and activity of SLC6 neurotransmitter
transporters are modulated by interaction with syntaxin 1A. Utilizing monocarboxylate-B 0
AT1/3 fusion constructs, we discovered that collectrin is also necessary for B 0 AT1 and B 0 …
expression and activity. The main apical membrane neutral amino acid transporters in
mouse intestine and kidney, B 0 AT1 and B 0 AT3, require the ancillary protein collectrin or
ACE2 for plasma membrane expression. Expression and activity of SLC6 neurotransmitter
transporters are modulated by interaction with syntaxin 1A. Utilizing monocarboxylate-B 0
AT1/3 fusion constructs, we discovered that collectrin is also necessary for B 0 AT1 and B 0 …
