Periostin is required for maximal airways inflammation and hyperresponsiveness in mice
JK Bentley, Q Chen, JY Hong, AP Popova, J Lei… - Journal of allergy and …, 2014 - Elsevier
Background Periostin, a secreted extracellular matrix protein, has been localized to deposits
of subepithelial fibrosis in asthmatic patients, and periostin levels have been linked to
increases in IL-13. Objective We hypothesized that periostin is required for airway
inflammatory responses to a physiologic aeroallergen, house dust mite (HDM). Methods We
studied F4-F6 B6; 129-Postn tm1Jmol/J wild-type (Postn+/+) and null (Postn−/−) mice, as
well as C57BL/6 mice treated with either IgM or OC-20 periostin neutralizing antibody. Mice …
of subepithelial fibrosis in asthmatic patients, and periostin levels have been linked to
increases in IL-13. Objective We hypothesized that periostin is required for airway
inflammatory responses to a physiologic aeroallergen, house dust mite (HDM). Methods We
studied F4-F6 B6; 129-Postn tm1Jmol/J wild-type (Postn+/+) and null (Postn−/−) mice, as
well as C57BL/6 mice treated with either IgM or OC-20 periostin neutralizing antibody. Mice …
