[HTML][HTML] The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains
H Tran, WJ VanDusen, WS Argraves - Journal of Biological Chemistry, 1997 - ASBMB
Fibulin-1 is a modular glycoprotein with amino-terminal anaphylatoxin-like modules followed
by nine epidermal growth factor (EGF)-like modules and, depending on alternative splicing,
four possible carboxyl termini. Fibulin-1 has been shown to self-associate as well as to bind
calcium, fibronectin (FN), laminin, nidogen, and fibrinogen. To map ligand-binding sites
within fibulin-1, polypeptides corresponding to various regions of fibulin-1 were expressed
recombinantly and evaluated for their capacity to bind calcium, FN, or fibulin-1. A calcium …
by nine epidermal growth factor (EGF)-like modules and, depending on alternative splicing,
four possible carboxyl termini. Fibulin-1 has been shown to self-associate as well as to bind
calcium, fibronectin (FN), laminin, nidogen, and fibrinogen. To map ligand-binding sites
within fibulin-1, polypeptides corresponding to various regions of fibulin-1 were expressed
recombinantly and evaluated for their capacity to bind calcium, FN, or fibulin-1. A calcium …