Perforin-2 is a highly conserved pore-forming protein encoded by macrophage expressed gene 1 (
Ryan M. McCormack, Eva P. Szymanski, Amy P. Hsu, Elena Perez, Kenneth N. Olivier, Eva Fisher, E. Brook Goodhew, Eckhard R. Podack, Steven M. Holland
Perforin-2 domains and locations of patient mutations.
Colored boxes indicate known domains of the perforin-2 protein. Amino acid ranges for each domain are as follows: signal peptide (SP) from 1–19; membrane-attack-complex-perforin (MACPF) from 30–345; perforin-2 (P2) from 351–653; transmembrane (TM) from 654–674; and cytoplasmic from 675–713. Patient mutations are indicated with arrows.