Judith E. Epstein, Kristopher M. Paolino, Thomas L. Richie, Martha Sedegah, Alexandra Singer, Adam J. Ruben, Sumana Chakravarty, April Stafford, Richard C. Ruck, Abraham G. Eappen, Tao Li, Peter F. Billingsley, Anita Manoj, Joana C. Silva, Kara Moser, Robin Nielsen, Donna Tosh, Susan Cicatelli, Harini Ganeshan, Jessica Case, Debbie Padilla, Silas Davidson, Lindsey Garver, Elizabeth Saverino, Tooba Murshedkar, Anusha Gunasekera, Patrick S. Twomey, Sharina Reyes, James E. Moon, Eric R. James, Natasha KC, Minglin Li, Esteban Abot, Arnel Belmonte, Kevin Hauns, Maria Belmonte, Jun Huang, Carlos Vasquez, Shon Remich, Mary Carrington, Yonas Abebe, Amy Tillman, Bradley Hickey, Jason Regules, Eileen Villasante, B. Kim Lee Sim, Stephen L. Hoffman
Consort 2010 flow diagram.
Thirty subjects were enrolled to receive 5 doses of 2.7 × 105 PfSPZ/dose at weeks 0, 4, 8, 12, and 20; subjects were then randomized equally to group 1 (homologous CHMIs) or group 2 (heterologous CHMIs). Fifteen subjects were enrolled to receive 3 doses of 4.5 × 105 PfSPZ/dose at weeks 0, 8, and 16 with homologous CHMIs (group 3, which began immunizations 1 month after groups 1 and 2). Twenty-four subjects were enrolled as infectivity controls for the total of 4 CHMIs (2 homologous CHMIs and 2 heterologous CHMIs); each CHMI included 6 infectivity controls, except heterologous CHMI #1, for which only 4 infectivity controls were challenged. CHMI, controlled human malaria infection.