Cystic Fibrosis (CF) is an autosomal recessive disease caused by mutations in CF transmembrane conductance regulator (
Ashley L. Cooney, Mahmoud H. Abou Alaiwa, Viral S. Shah, Drake C. Bouzek, Mallory R. Stroik, Linda S. Powers, Nick D. Gansemer, David K. Meyerholz, Michael J. Welsh, David A. Stoltz, Patrick L. Sinn, Paul B. McCray Jr.
Correction of chloride (Cl–) transport in cystic fibrosis (CF) pig primary epithelial with a lentiviral vector.
Feline immunodeficiency virus–based viral vector expressing cystic fibrosis transmembrane conductance regulator (FIV-CFTR; MOI = 5) was delivered to the apical surface of well-differentiated primary cultures of airway epithelial cells from CF pigs. Transepithelial Cl– currents were measured in Ussing chambers. (